Tissue engineering is the use of a combination of cells, engineering and materials methods, and suitable biochemical and physiochemical factors to improve or replace biological functions. This course teaches fundamentals that span several academic areas related to tissue engineering to students who have a mechanical engineering background, and introduces various approaches to research. Topics include basic cell biology, chemistry, biomaterials, anatomy, computer-aided design/computer-aided machining (CAD/CAM), and manufacturing technology. Various mathematical and mechanical tools for simulating cell behavior are introduced. In addition, basic experimental laboratory instruction covers cell culture and scaffold fabrication.

Homework assignments: 20 %
Mid-term: 30 %
Term project: 40 %
Attendance: 10 %

1. Robert Lanza, Robert Langer and Joseph P. Vacanti, “Principles of Tissue Engineering, 4th Edition,” Academic Press, 2013
2. Gabor Forgacs and Wei Sun, “Biofabrication,” Elsevier, 2013
3. James J. Yoo and Il-Woo Lee, “Regenerative Medicine (2nd ed.),” Koonja, 2018

Week 1: Overview of the course & Introduction of tissue engineering

Week 2~3: Basic cell biology & ECM
- Introduction of basic cell biology
- Stem cells
- Culturing Mammalian Cell
- Controlling the Cell Culture Environments

Week 4~5: Basic cell culture (practice)
- Fabrication of scaffolds using 3D bioprinting
- Cell counting and cell seeding to scaffolds
- Functional analysis (CCK-8, RT-PCR, IF)

Week 6~7: Biomaterials & Scaffolds
- Overview
- Specific biodegradable polymer
- Scaffolds

Week 8: Term project proposal presentation & Mid-term exam

Week 9~11: Computer-Aided Tissue Engineering
- Biomedical application of 3D printing
- Advanced programs for printing path generation: A key element of 3D bioprinting
- 3D Tissue/Organ Printing

Week 12: Basic anatomy

Week 13~14: Case studies & Future perspective
- Bone
- Cartilage
- Soft tissues (Blood vessel, Adipose, Skeletal muscle, Liver,)

Week 15~16: Term project final presentation

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