3. 강의목표
This course will be focused on the design and synthesis of organic compounds including natural products, with emphasis on the modern synthetic methodologies, reaction mechanisms and stereochemistry. In addition, to foster students’ ability to orchestrate organic reactions, students are supposed to present a literature seminar on a natural product synthesis and also a project of retrosynthetic analysis for a selected natural product.
4. 강의선수/수강필수사항
Organic Chemistry I/II, preferred
5. 성적평가
(1) Literature seminar: 30%
(2) Retrosynthetic analysis project: 50%
(3) Others (assignments or exam): 20%
6. 강의교재
| 도서명 |
저자명 |
출판사 |
출판년도 |
ISBN |
|
Classics in Total Synthesis
|
K.C. Nicolaou, E.J. Sorensen
|
VCH, Weinheim
|
1996
|
|
|
Classics in Total Synthesis Ⅱ
|
K.C. Nicolaou, S.A. Snyder
|
Wiley-VCH, Weinheim
|
2003
|
|
|
Modern Methods of Organic Synthesis
|
Carruthers, W.; Coldham, I.
|
Cambridge, University Press
|
2004
|
|
|
The Logic of Chemical Synthesis
|
E.J. Corey, X.-M. Cheng
|
John Wiley & Sons, N.Y.
|
1989
|
|
7. 참고문헌 및 자료
1. Bruckner, R. “Advanced Organic Chemistry, Reaction Mechanisms”, Harcourt, NY, 2002
2. Comprehensive Organic Chemistry, by Barton and Ollis (Ed.), vol.1-6, Pergamon, 1979
3. Comprehensive Organic Synthesis, B. M. Trost Ed., Vol. 1-9, Pergamon, 1991
4. K. C. Nicolaou, E. J. Sorensen, “Classics in Total Synthesis”, VCH, Weinheim, 1996.
5. K. C. Nicolaou, S. A. Snyder, “Classics in Total Synthesis II”, Wiley-VCH, Weinheim, 2003
6. Journal Articles from J. Am. Chem. Soc., Angew. Chem. Int. Ed., Chem. Commun., and Organic Letter, etc.
8. 강의진도계획
1. Formation of carbon-carbon single bonds-Main group chemistry
2. Formation of carbon-carbon single bonds-Transition metal chemistry
3. Formation of carbon-carbon double bonds
4. Pericyclic reactions
5. Radical and carbene chemistry
6. Functionalization of alkenes
7. Oxidation
8. Reduction
9. Ester- and Amide-Coupling Reactions
9. 수업운영
- Lecture materials will be provided as pdf files
- Guidelines for the literature seminar and presentation project will be given
- The retrosynthetic project will be conducted through steps: 1) selection of the target molecule, 2) identification of key steps, 3) detailed synthetic steps, and 4) finalization of the retrosynthetic analysis. Students are supposed to have discussions with Professor at each step.
- The lecture will be given in English
10. 학습법 소개 및 기타사항
This course is recommended for the graduate/undergraduate students who have strong background in Organic Chemistry.
11. 장애학생에 대한 학습지원 사항
- 수강 관련: 문자 통역(청각), 교과목 보조(발달), 노트필기(전 유형) 등
- 시험 관련: 시험시간 연장(필요시 전 유형), 시험지 확대 복사(시각) 등
- 기타 추가 요청사항 발생 시 장애학생지원센터(279-2434)로 요청