This course provide students with an in-depth understanding of the fundamentalconcepts (physical chemistry, chemistry, and materials science) behind the design of materials with biological functions at a molecular scale. In addition, the course includes the introduction to recent advances in drug delivery, tissue engineering, biosensors and bioimaging with nanoparticles.

Basic sciences on materials, biology, chemistry, and physics

Discussion during the course (10%), Project presentation (20%), Mid-term exam (30%), Final exam (40%)

Biomaterials Science: An Introduction to Materials in Medicine, 2nd Edition, 2004
- Principles of tissue engineering (Academic Press)
- Pharmaceutical biotechnology (Taylor and Francis)
- Modern biopharmaceuticals (Wiely-CCH)
- Nanobiotechnology (Wiely-CCH)
- Principals of biochemistry (Lehninger)
- MIT open course ware (MIT OCW, http://ocw.mit.edu/index.html)

[1 WK] Introduction to biomaterials science - Course syllabus, Research trend in biomaterials science
[2 WK] A history of biomaterials science - Biomaerials, Drug delivery system, Tissue engineering
[3 WK] Biochemistry for biomaterials science I - Fundamentals on cells, Protein and peptide
[4 WK] Biochemistry for biomaterials science II - Nucleic acid : DNA and RNA, Oligonucleotide drugs
[5 WK] Polymeric biomaterials - Biodegradable polymers, Synthesis of biodegradable polymers, Biodegradation of polymers
[6 WK] Hydrogel biomaterials - Hydrogels in biomaterials science, Structures of various hydrogels, Polyelectrolyte complex
[7 WK] Inorganic biomaterials - Permanent devices/implants, Biomimesis of bone, Organic templating of inorganic biomaterials
[8 WK] Project proposal by students and Mid-term exam
[9 WK] Blood-biomaterials interactions - Basic concepts, Blood compatibility
[10 WK] Biological recognition of biomaterials - Interactions of biomaterials with cells, Engineering biological recognition
[11 WK] Basics in drug delivery - Pharmacokinetics and pharmacodynamics, Drug delivery routes, Intracellular drug delivery
[12 WK] Drug delivery systems - Drug-polymer conjugates, Nano- and micro-drug carriers, Drug delivery devices
[13 WK] Basics in tissue engineering - Stem cells, Tissue scaffolds and growth factor, In vitro and in vivo cell culture
[14 WK] Tissue engineering case study - Commercialized medical devices, Cell therapy, Organ replacement therapy
[15 WK] Nano-Bio science and engineering * Advanced molecular devices * Quantum dot sciences * Biosensors
[16 WK] Project presentation and Final exam