Tissue engineering is the use of a combination of cells, engineering and materials methods, and suitable biochemical and physiochemical factors to improve or replace biological functions. This course teaches fundamentals that span several academic areas related to tissue engineering to students who have a mechanical engineering background, and introduces various approaches to research. Topics includes integrated knowledge covering biomaterials, cells, biofabrications, biologically inspired systems and biomanufacturing for translating technologies to advanced tissue therapeutics (in e.g. cardiovascular system, bone, skin, cartilage..).

Written assignments: 30 %
Journal club: 20 %
End-term: 40 %
Attendance: 10 %

1. Robert Lanza, Robert Langer and Joseph P. Vacanti, “Principles of Tissue Engineering, 5th Edition,” Academic Press, 2020
2. Gabor Forgacs and Wei Sun, “Biofabrication,” Elsevier, 2013
3. James J. Yoo , Il-Woo Lee, and Moonsuk Kim “Regenerative Medicine (5th ed.),” Koonja, 2023

Week 1: Overview of the course & Introduction of tissue engineering
Week 2~4: Biological Materials
– Design principles of biomaterials
– Natural and synthetic polymers
– Ceramics and hybrid biomaterials
– Scaffolds and nanoparticles
– Drug delivery and tissue engineering
Week 5~6: Tissue development
– Engineering tissue morphogenesis
– Neovascularization
– Extracellular matrix (Niche)
Week 7~8: Enabling technologies
– Biofabrication
– Bioinks design
– In-situ tissue engineering
– Sensors for tissue engineering
– Smart biomaterials and nanobiotechnology
– Microfluidics and Tissue-Chip
Week 9~10: Cells and biology
– Basic cell biology (cellular structures)
– Cell-cell communications
– Immune response and inflammation
– Bioactive actors for regulating regeneration
– Stem cells and organoids
Week 11: Written assignments & Exam
Week 12~13: Case study
– Bone & Cartilage
– Soft tissues (Blood vessel, Adipose, Skeletal muscle, Liver)
Week 14~16: Journal club presentation
– Nano-biomaterials-oriented
– Stem cell-oriented
– Biofabrication-powered

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