This interdisciplinary course examines the physical basis of life through molecular interactions, the structure and dynamics of large biomolecules, and cellular mechanics.
It also introduces modern biophysical techniques, including fluorescence methods, advanced microscopy, and single-molecule experiments, with an emphasis on quantitative analysis and modeling.
The course is designed for advanced undergraduate and graduate students in the physical and biological sciences.

A basic background in both physics and biology is helpful, but not strictly required.

- Jay L. Nadeau, Introduction to Experimental Biophysics: Biological Methods for Physical Scientists 2nd Edition (CRC Press, 2017)
- Wokyung Sung, Statistical Physics for Biological Matter (Springer, 2018)
- David S. Goodsell, The Machinery of Life (Springer, 2009)

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Weeks 1–8: Foundations & Statistical Biophysics
Week 1: Fundamental Principles
Week 2: Building Blocks
Week 3: Random Processes
Week 4: Polymers
Week 5: Protein Folding & Conformations
Week 6: Single-Molecule Techniques
Week 7: Buffer for the 1st Half
Week 8: Midterm
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Weeks 9–16: Interactions, Cells & Imaging
Week 9: Interactions
Week 10: Reactions
Week 11: Cellular Organization
Week 12: Cellular Signaling & Mechanobiology
Week 13: Neurons
Week 14: Microscopy
Week 15: Buffer for the 2nd Half
Week 16: Final

- Classroom lectures
- Lecture notes will be provided in advance.