This course introduces the fundamental principles of biochemistry, with an emphasis on understanding the relationships among molecular structure, chemical interactions, and biological function. Students will develop the ability to apply these principles to understand biochemical mechanisms and interpret experimental data, while connecting fundamental concepts to contemporary research.

A basic understanding of general chemistry and organic chemistry is recommended. Prior coursework in biology is helpful but not required.

Nelson, D. L. and Cox, M. M. Lehninger Principles of Biochemistry, 8th Edition.

Additional lecture materials, selected research articles, structural and biochemical data, and other supplementary resources will be provided throughout the course when appropriate.

Week 1. Biochemistry: An Evolving Science
Week 2. Protein Structure and Function
Week 3. Exploring Proteins and Proteomes
Week 4. Enzymes: Kinetics and Catalysis
Week 5. Enzyme Regulation and Allostery
Week 6. Lipids, Membranes, Channels, and Pumps
Week 7. DNA, RNA, and the Flow of Genetic Information
Week 8. Midterm Examination
Week 9. Bioenergetics and the Logic of Metabolism
Week 10. Glucose Metabolism: Glycolysis, Gluconeogenesis, and Glycogen
Week 11. Citric Acid Cycle and Oxidative Phosphorylation
Week 12. Metabolic Integration and Fuel Metabolism
Week 13. Signal Transduction
Week 14. Frontiers in Molecular and Membrane Biochemistry
Week 15. From Molecular Mechanism to Discovery
Week 16. Final Examination

This course will combine lectures with problem solving, discussion, and interpretation of biochemical and structural data. Fundamental biochemical concepts will be introduced through lectures and progressively connected to experimental observations and contemporary research. In the later part of the course, students will apply these concepts to analyze molecular mechanisms and research questions.

Lecture notes and related materials will be uploaded to e-Class before each class. Students are encouraged to review the lecture materials in advance. Selected biochemical problems, molecular structures, and research figures may be discussed during class. Active participation and scientific discussion are encouraged.