Fluorinated compounds have been of great interest for many applications such as pharmaceuticals, agrochemicals, fluoro plastics (Teflon), and 18F-labeled radiopharmaceutical imaging agents because of the benefits from fluorine’s unique properties such as thermal and oxidative stability and lipophilicity to enhance bioavailability. For example, strong C-F bonds on the fluorine-containing material such as Teflon®, Nafion, and PFA (perfluoroalkoxy) enable a low polarity, small surface tension and reflective index, which are desired properties of waterproof and insulating materials. Approximately 25% of current pharmaceuticals and 30% of agrochemicals contain fluorine. Although there was considerable demand for facile preparation of fluorinated compounds, the methods have been significantly developed only for the past two decades. From these lectures, I will discuss the early fluorination history and then move on to the recent development including reagent based and transition metal-catalyzed fluorination. In addition, [18F]fluorination methods will be discussed. Finally, the efforts to disconnect the strong C-F bonds will be described for useful applications.

By the end of this course, you will be able to
1. understand the importance of C-F bonds in many applications as an interdisciplinary course.
2. design a new synthetic route for fluorinated organic molecules.
3. know radiochemistry.
4. understand different views on C-F bond cleavage.
5. know the importance of fluorinated drugs and polymers.

화학/화공/신소재 대학원생을 대상으로 불소화학을 통한 융합학문(신약개발, 고분자화학유기금속 화학, 방사성 화학)을 가르친다.

Exam: 30%, Presentation: 30% Report: 30%, Attendance & ASAP Review (10%)

Thomas Braun; Russell P. Hughes, Organometallic Fluorine Chemistry Topics in Organometallic Chemistry, Springer (2015).
Chemical Reviews, 2015 FLUORINE CHEMISTRY REVIEWS January 28, 2015 Volume 115, Issue 2 Pages 563-1306.

1. Basic organometallics
2. The early history of fluorination
3. Fluorination reagents
4. Nucleophilic and electrophilic fluorination
5. Aliphatic and aromatic fluorination
6. Fluorination for positron-emission tomography (PET) and radiopharmaceuticals
7. Activation and functionalization of C-F bonds
8. Fluorinated Polymers: history, synthesis, and application (energy and electronic materials)
9. Fluorinated Drugs and Agrochemicals: fluorine-based blockbuster drugs and future directions
10. Positron-emission tomography (PET) lectures (Bundang SNU Hospital, Yonsei Hospital)
11. Current new fluorination methods

교수/학습방법: 이론강의 등